Role of hypermodified bases in transfer RNA. Solution properties of dinucleoside monophosphates

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Role of hypermodified bases in transfer RNA. Solution properties of dinucleoside monophosphates.

The hypermodified dinucleoside monophosphates, uridylyl(3’-5’)-N-[9-(~-~-ribofuranosyl)purin-6ylcarbamoyl]threonine (Upt6A), adenylyl(3’-5’)-N6-(A2isapenteny1)adenosine (ApihA), adenylyl( 3’-5’)-N6-( A2-isopentenyl)-2-methylthioadenosine (Apms2i6A), and adenylyl(3’-5’)-l ,N6-ethenoadenosine (AptA, a synthetic model for adenylyl(3’-5’)wybutosine, ApyW), which represent the most common sequences ...

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Nucleotides. VI. Syntheses and spectral properties of some deazaadenylyl-deazaadenosines (dinucleoside monophosphates with unusual CD-spectrum) and closely related dinucleoside monophosphates.

Nine dinucleoside phosphates containing 1-deaza-(1A) and 3-deazaadenosine (3A) were prepared. Hypochromicity and CD spectra of these dimers were determined. It was found that varying degrees of base-stacking are operative with these oligonucleotides and their CD spectra fall into three classes. The first class CD spectra which are more or less similar in profile to those of adenylyl-(3'-5')-ade...

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ژورنال

عنوان ژورنال: Biochemistry

سال: 1978

ISSN: 0006-2960,1520-4995

DOI: 10.1021/bi00605a033